Clinical Evidence

05
Feb
4 min read

The Post-Hoc Problem: Why Bayesian Pre-Specification Matters More Than the Philosophy

The Bayesian vs. frequentist debate usually centers on philosophy. Priors are subjective! No, they formalize existing knowledge! You're smuggling in assumptions! You're ignoring relevant information! It's a fun argument. It's also the wrong one, at least for regulatory decision-making. The real value